GERMINOMA MEDIASTINUM PDF

The mediastinum is the most common extragonadal location. In adults, approximately % of mediastinal tumors are germ cell tumors;. 20% of mediastinal tumors and cysts; Typically divided into seminomas versus nonseminomatous germ cell tumors (teratomas [mature or. Mediastinal germ cell tumors are tumors that derive from germ cell rest remnants in the mediastinum. They most commonly occur in the gonad but occasionally.

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Germinoma-seminoma is the most frequent nonteratomatous malignant germ cell tumor. In addition to physical examination and routine laboratory studies, initial evaluation should include CT of the chest and abdomen, and determination of serum levels of HCG and alpha-fetoprotein.

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Mediastinal germ cell tumor – Wikipedia

Monday 23 January The intense staining pattern of OCT4 and the high sensitivity of FISH make them superior to other auxiliary diagnostic utilities for detecting seminoma. The majority of neoplasms are germinmoa cystic teratomas that are incidentally discovered on imaging studies of the thorax.

These neoplasms are often associated with the thymus, and in many cases appear to have originated in the thymus; residual thymic tissue is not identifiable in the highly invasive and malignant germ cell tumor. Excised tumor with rib.

Germ cell tumors of the mediastinum.

Patients with small tumors usually asymptomatic that appear resectable usually undergo thoracotomy and attempted complete resection followed by chemotherapy. April Learn how and when to remove this template message.

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This page was last edited on 2 Augustat This website is intended for pathologists and laboratory personnel, germjnoma understand that medical information is imperfect and must be interpreted using reasonable medical judgment. Nasal cavity Esthesioneuroblastoma Nasopharynx Nasopharyngeal carcinoma Nasopharyngeal angiofibroma Larynx Laryngeal cancer Laryngeal papillomatosis.

Gestational trophoblastic disease Hydatidiform mole Choriocarcinoma Placental site trophoblastic tumor Polyembryoma Gonadoblastoma. Usually males ages 20 – 49 years, similar to gonadal tumors Cancer ; Unlike benign germ cell tumors of the mediastinum, malignant mediastinal tumors are usually symptomatic at the time of diagnosis.

Malignant mediastinal germ cell tumors of various histologies were geminoma described as a clinical entity approximately 50 years ago.

Epidemiology Usually males Gross description Invasive, highly necrotic Microscopic histologic description Poorly differentiated, pleomorphic cells with prominent nucleoli, often with eosinophilic intracellular globules or primitive lumina; variable geographic necrosis No nuclear blebs Microscopic histologic images Images hosted on other servers: Non-small-cell lung carcinoma Squamous-cell carcinoma Adenocarcinoma Mucinous cystadenocarcinoma Large-cell lung carcinoma Rhabdoid carcinoma Sarcomatoid carcinoma Carcinoid Salivary gland—like carcinoma Adenosquamous carcinoma Papillary adenocarcinoma Giant-cell carcinoma.

Metastatic germ cell tumor: Germ cell tumors[TI] mediastinum. The diagnosis of a mediastinal germ cell tumor should be considered in all young males with a mediastinal mass. Thymic seminoma with marked cystic changes, superior mediastinum. Am J Surg Pathol.

Sign up for our Email Newsletters. Immunohistochemical staining for OCT4 has recently been validated as a powerful tool for detecting gonadal seminoma. However, the cardiotoxicity of mediastinal radiation is substantial and the standard treatment of mediastinal seminomas is with chemotherapy using bleomycinetoposide and cisplatin for either three or mediatsinum day treatment cycles depending on the location of any metastatic disease.

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These results and those of other analyses suggest that the two malignancies derive from a gsrminoma founding clone of cells i. Histologic grading of pure teratomas has prognostic significance in those neoplasms germinoja are diagnosed in adolescents and young adults; immature teratomas in the latter patients pursue an aggressive clinical course.

In these cases, the mediastinal germ cell tumor develops before or concomitantly with but not after acute megakaryoblastic leukemia.

Fine needle aspiration biopsy can establish diagnosis with high degree of accuracy Am J Clin Pathol ; Among the malignant germ cell tumors, males are affected far more commonly than females, but the male mediastinun female ratio is approximately equal among mature cystic teratomas.

mediastinal germinoma – – Human pathology

New author database being installed, click here for details. Epidemiology Usually men in 20s with elevated hCG and gynecomastia, impotence Prognostic factors Poor prognosis Case reports 13 year old boy with shortness of breath, chest pain, fever, irritable mediaetinum and weight loss Zhongguo Dang Dai Er Ke Za Zhi ; Mediastinum Other malignancies Germ cell tumors Author: Germ cell tumor gerkinoma mixed.

Sarcoma Lymphoma Immature teratoma Melanoma. By using this site, you agree to the Terms of Use and Privacy Policy. Pure mediastinal seminomas are curable in the large majority of patients, even when metastatic at the time of diagnosis.