Erythema nodosum (EN) is an acute, nodular, erythematous eruption that usually is limited to the extensor aspects of the lower legs. Chronic or. English Turkish online dictionary Tureng, translate words and terms with different pronunciation options. WebMD explains erythema nodosum, a skin condition that usually affects the lower legs, including causes, symptoms, diagnosis, and.

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These lesions do not have a tendency to necrosis and resolve spontaneously within 2—8 weeks without leaving scars. Acquired generalized lipodystrophy partial: Skin disorders, after arthritis, uveitis and aphthous stomatitis, are one of the most common extra-intestinal manifestations of inflammatory bowel diseases IBD.

Otherwise during diagnosis, oncological vigilance should be maintained, because erythema nodosum may be a paraneoplastic symptom appearing mostly in the course of lymphoma and leukaemia [ 12 ]. This page was last edited on 24 Decemberat Author information Article notes Copyright and License information Disclaimer. It may be accompanied by systemic symptoms such as fever, malaise and arthralgia [ 1 — 4 ]. Erythema nodosum occurs among 4. Epidermal wart callus seborrheic keratosis acrochordon molluscum contagiosum actinic keratosis squamous-cell carcinoma basal-cell carcinoma Merkel-cell carcinoma nevus sebaceous trichoepithelioma.

It is presumed that it is related to local anatomical circumstances. Erythema nodosum usually occurs in the first trimester of pregnancy when the level of progesterone is lower than in the next stage of gestation. Mycobacterium tuberculosis infection is associated with the development of erythema nodosum and nodular vasculitis. It appears as erythematous painful rounded nodules, located most often on the anterior surface of the lower extremities, and may be accompanied by systemic symptoms such as fever, malaise and arthralgia.


Acquired partial lipodystrophy Centrifugal abdominal lipodystrophy HIV-associated lipodystrophy Lipoatrophia annularis localized: HRCT provides better diagnostic performance of lung alterations such as hilar adenopathy or nodular infiltrates compared to chest X-ray.

Erythema nodosum appears generally 2—3 weeks after eeitema of pharyngitis. It can be caused by a variety of conditions, and typically resolves spontaneously within 30 days.


A sign of systemic disease”. Dermatographic urticaria Vibratory angioedema Pressure urticaria Cholinergic urticaria Aquagenic urticaria.

Autoimmune diseases Erythemas Reactive neutrophilic cutaneous conditions Conditions of the subcutaneous fat Medical mnemonics.

The high incidence of EN in females suggests that eriteam is related to sex hormones, confirmed by the more frequent occurrence during pregnancy and when using oral contraceptive pills. Evaluating the clinical significance of erythema nodosum.


Andrews’ Diseases of the skin: Cutaneous manifestations of Takayasu arteritis. Confirmation of the hypothesis may be the fact that EN occurs with the same frequency in men and women in the prepubertal period. EN can be treated by both dermatologists and rheumatologists — our clinical experience has shown that patients with erythema nodosum are referred noddozum often to a rheumatologist than to a dermatologist if peripheral joints are involved.

In addition, there are suggestions that genetic factors also play a role in the pathogenesis of skin lesions in IBD — mainly variants of the TRAF3IP2 gene encoding a protein involved in inflammatory reactions by activating cytokines.

The redness starts to fade and it gradually becomes softer and smaller until it disappears. It may have many aetiological factors.

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Erythema nodosum – review of the literature

Fitzpatrick’s color atlas and synopsis of clinical dermatology 5th ed. Received Mar 13; Accepted Apr Administration of tamoxifen and anti-estrogens such as aromatase inhibitors was associated with occurrence of the EN [ 4 ].

Haemorrhages can be seen in the early phase of erythema nodosum as a result of infiltration of neutrophils around proliferating capillaries. Retrieved from ” https: Sarcoidosis Sarcoidosis is the second most common cause of EN. The histopathological signs of erythema nodosum are characterized by septal inflammation of subcutaneous fat tissue septal panniculitis.

For this reason, development of skin lesions in patients with previously treated malignancy requires oncological vigilance. The skin of the extensor surface of the lower legs is characterized by a lack of underlying muscle pump and unique coexistence of relatively poor arterial blood supply, rich lymphatic system and difficult venous return caused by gravitational effects. There are some reports that erythema nodosum in patients with Crohn’s disease is associated with the T-cell immune response to common antigens of intestinal and skin bacteria.

It is also worth mentioning that oestradiol takes part in up-regulation of TNF, which can potentially be an important factor determining the frequency of developing of EN between the genders. Erythema nodosum as a paraneoplastic syndrome Erythema nodosum may be the first sign of norozum existent neoplastic disease.

Erythema nodosum is diagnosed clinically.